The Children’s Cancer Centre (CCC) Tissue Bank is a world-class resource for researchers studying childhood and adolescent/young adult (AYA) cancer. The CCC Tissue Bank also includes patients with inherited bone marrow failure syndromes (IBMFS) and associated disorders, primary immunodeficiency disease and Neurofibromatosis (plexiform neurofibroma only). The CCC Tissue Bank stores leftover samples from clinical tests and takes additional collections, including samples from siblings, parents or other relatives. These samples can be used for further clinical testing and ethically approved research.  Started in 2014, there are samples from over 1000 patients and over 10,000 primary specimens (as of March 2019).

The CCC Tissue Bank provides valuable samples for national and international research projects.  Without these samples, researchers cannot make a difference to improving the outcomes for children and AYAs with cancer. Samples allow researchers to: understand the molecular mechanisms which lead to cancers in children and AYAs, establish new molecular-based diagnostic tests which will assist with the selection of the most appropriate treatments, investigate tumour biology using cell lines, test new drugs and therapies before use in the clinic, identify new targets for therapy, and reduce the debilitating side effects of treatment.



Year 2014 – ongoing
Age 0 – 25 years (cases)
# > 1000 as of March 2019
Time Point Diagnosis/pre-treatment Treatment Post-treament/
monitoring
Relapse
Condition specific information
Demographics
General health
Imaging
Medications and supplements
Bioanalyses and omics
Biosamples
Study Summary
Study name Children’s Cancer Centre Tissue Bank
Study abbreviation CCC Tissue Bank
Current principal investigator/s Jordan Hansford (PI)
Louise Ludlow (AI)
Richard Saffery (AI)
Current project manager Louise Ludlow
Primary Institution Murdoch Children’s Research Institute
Collaborating Institution/s The Royal Children’s Hospital
Major funding sources Murdoch Children’s Research Institute
Study website www.mcri.edu.au/childrenscancercentretissuebank
Are data available to others outside study team? If you would like to access samples and data please contact the CCC Tissue Bank Coordinator (Louise Ludlow) by e-mail.
Study focus (e.g. social development) Cancer
Sampling frame The Royal Children’s Hospital
Study type (e.g. randomised control trial, cohort, case-control) Tissue bank
Year commenced 2014
Ongoing recruitment? Yes
Current sample (N) 1033 (as of March 2019)
Annual recruitment rate 200
Intergenerational (e.g. offspring)? No
Imaging (e.g. fMRI, ultrasound, retinal photograph)? Yes – Access to imaging reports only
Linkage (e.g. BioGrid, VPDC, NAPLAN, Medicare)? Yes, consent obtained for linkage to the medical record in future
Biosamples (e.g. buccal, blood, hair)? Over 10,000 primary specimens (as of March 2019)
Blood
Buccal
Newborn screening (Guthrie) card
Saliva
Bone marrow
Post-operative tumour specimens
Fluid
Cell line generation
Ethics approvals or requirements (e.g. specific, extended, unspecified, other)? Future research related to this project (Extended consent)

Principal Investigator

Francoise Mechinaud

Project Manager

Louise Ludlow

Study Contact

Louise Ludlow
Ph: +613 9936 6048
Email: louise.ludlow@mcri.edu.au

Postal Address

Murdoch Childrens Research Institute
The Royal Children’s Hospital
50 Flemington Road
Parkville VIC, 3052
Australia