Childhood Overweight BioRepository of Australia (COBRA)
COBRA (Childhood Overweight BioRepository of Australia) is a comprehensive repository of data and biological samples, established in 2009, from overweight and obese children and their families.
Obesity in early life is associated with many adverse effects on health, including an increased risk of type 2 diabetes (T2DM), heart and liver disease. Unfortunately, to date, traditional methods of research have failed to identify effective prevention and treatment strategies, and large numbers of children and adolescents continue to be at high risk of developing weight-related disease.
By collecting baseline environmental, clinical and anthropometric data, biological samples for genetic, metabolic and hormonal profiles, and incorporating opportunities for longitudinal data collection into the study design, COBRA will enable researchers to better understand the complex interplay between environmental and genetic factors that govern disease risk.
| Year | 2009-Ongoing | 2009-Ongoing |
|---|---|---|
| Phase | Baseline | Clinic Visit |
| Age | 2-18 years | 2-18 years |
| N | in progress | in progress |
| RELEVANT LIFECOURSE DOMAINS | Allergies | |
| Anthropometrics | ||
| Bioanalyses and omics | ||
| Biosamples | ||
| Cardiovascular health | ||
| Community environment | ||
| Demographics | ||
| Education and childcare | ||
| Environmental exposures | ||
| Family environment | ||
| Health services | ||
| Medications and supplements | ||
| Mental health and behaviour problems | ||
| Methodology | ||
| Neurocognitive development | ||
| Nutrition | ||
| Other health information | ||
| Peer relationships | ||
| Physical activity | ||
| Pregnancy and birth | ||
| Psychosocial wellbeing | ||
| Puberty | ||
| Respiratory health | ||
| Screen and technology use | ||
| Sleep | ||
| Substance use | ||
| Study Summary | |
|---|---|
| Study name | Childhood Overweight BioRepository of Australia |
| Study abbreviation | COBRA |
| Current principal investigator/s |
Matt Sabin David Burgner Richard Saffery |
| Current project manager |
Brooke Harcourt |
| Primary Institution/s |
Murdoch Children’s Research Institute - MCRI
|
| Collaborating Institution/s |
Cincinnati Children’s Hospital Medical Center |
| Major funding source/s |
Murdoch Children’s Research Institute - MCRI The Royal Children’s Hospital Foundation - RCHF |
| Key reference for study | Sabin, M.A., Clemens, S.L., Saffery, R., McCallum, Z., Campbell, M.W., Kiess, W., Crimmins, N.A., Woo, J.G., Leong, G.M., Werther, G.A., Ukoumunne, O.C. and Wake, M. A. (2010). New directions in childhood obesity research: how a comprehensive biorepository will allow better prediction of outcomes. BMC Medical Research Methodology, 10: 100 |
| Study focus |
To develop a unique repository of data and biological samples from overweight and obese children and their families, incorporating opportunities for longitudinal data collection into the study design |
| Sampling frame |
Presentation to the specialist weight management service at The Royal Children’s Hospital (Melbourne) |
| Primary study type | Databank / Biobank |
| Primary participant (at recruitment) | Index child |
| Year commenced |
2009 |
| Is this study ongoing? | Yes - the study is ongoing |
| Ongoing recruitment? | Yes |
| Sample size (N) |
~500 as of June 2016 |
| Survey data available? | Yes |
| Imaging data available? | No |
| Linkage to administrative dataset/s? | No, no consent to link to administrative dataset(s) obtained |
| Biosamples available? | Yes |
| Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? | Yes |
| Are there any costs associated with data/sample access for approved requests? | There are usually no costs associated with access |
| Broadest type of participant consent available |
Unspecified consent (can be used for any future ethically approved research) |
| Study Contacts | |
|---|---|
| Principal investigator/s |
Matt Sabin David Burgner Richard Saffery |
| Project manager |
Brooke Harcourt |
| Study Contact |
Email: growing.healthy.kids@mcri.edu.au |