LifeCourse A Melbourne Children's Research Initiative

COBRA: Bioanalyses and omics

Relevant LifeCourse Constructs	Year	2009-Ongoing	2009-Ongoing
	Phase	Baseline	Clinic Visit
	Age	2-18 years	2-18 years
	N	in progress	in progress
Epigenotyping				BA:CEpi ^I
Gene expression assay				BA:COBRA ^I
Genotyping				BA:CGen ^I
Hormone measurement				BA:C-HM ^I ¹
Metabolic function test				BA:C-MA ^I ²
Renal function				BA:COBRA ^I
Vitamin D measurement				BA:COBRA ^I

Featured measurements

CEpi: : Candidate Epigenotyping Protocol
CGen: : Candidate Genotyping Protocol
COBRA: : Childhood Overweight BioRepository of Australia Study-devised measure
C-HM: : COBRA Devised - Hormone Measurement Protocol
C-MA: : COBRA Devised - Metabolic Analyses measure

Notes

Hormone measurements on blood and urine samples included (for example) FSH, LH, PTH, testosterone, androgen, thyroid function, adiponectin, leptin, resistin. For further information, contact COBRA

Metabolic profile analyses on blood samples included liver function, lipid profile, insulin, glucose (fasting for < 10 year olds, oral glucose tolerance test for ≥ 10 year olds), vitamins and minerals. For further information, contact COBRA

Legend

B: = Biosample collected
BA: = Biosample analysis
G: = Grandparent(s) completed questionnaire
L: = Data linkage
N: = Nurse completed questionnaire
O: = Observation or direct assessment
Of: = Offspring completed questionnaire
P: = Parent/guardian completed questionnaire
Pe: = Peer completed questionnaire
R: = Records abstraction
S: = Self (primary participant) completed questionnaire
T: = Teacher completed questionnaire
X: = Other source
X ^F: = Pertains to father
X ^Fam: = Pertains to family
X ^G: = Pertains to grandparent(s)
X ^I: = Pertains to primary participant
X ^IP: = Pertains to partner
X ^M: = Pertains to mother
X ^O: = Pertains to offspring
X ^P: = Pertains to parent/guardian(s)
X ^Pe: = Pertains to peers
X ^Si: = Pertains to sibling(s)
X ^T: = Pertains to teacher(s)
X ^X: = Pertains to other reportees

Metadata presented by LifeCourse provides a crucial first step in understanding the available data across studies. It does not take the place of detailed study documentation, which should always be consulted during design and analysis.