The Triple B Pregnancy Cohort Study (Bumps, Babies and Beyond) is an innovative new Australian study of 1800-2000 families. The project is a longitudinal birth cohort which examines a wide range of biopsychosocial factors that relate to the health and development of Australian children and families. Importantly, the project has a key focus on examining the impacts of alcohol, tobacco and other drug use in pregnant women and their partners during the prenatal period on infant development and family functioning. The results of this study will inform public health and treatment initiatives that improve the health and well-being of Australian children and families.This project is sometimes referred to by its scientific title, ‘The impact of parental alcohol, tobacco and other substance use on infant development and family functioning’.



 

Study Summary
Study name The Triple B Pregnancy Cohort Study (Bumps, Babies and Beyond)
Study abbreviation Triple B
Current principal investigator/s Dr Delyse Hutchinson – Triple B Scientific Director
Professor Richard Mattick – NHMRC Principal Research Fellow
Current project manager Dr Delyse Hutchinson
Primary Institution University of New South Wales (UNSW)
Collaborating Institution/s Curtin University
Deakin University
University of Queensland
University of Sydney
Royal Prince Alfred Hospital
Murdoch Children’s Research Institute
Macquarie University
Major funding sources National Health and Medical Research Council
Study website http://ndarc.med.unsw.edu.au/project/triple-b-bumps-babies-and-beyond
Key reference for study (published study protocol) Hutchinson, D., Wilson, J., Allsop, S., Elliott, E., Najman, J., Burns, L., Bartu, A., Jacobs, S., Honan, I., McCormack, C., Rossen, L., Fiedler, H., Stone, C., Khor, S., Ryan, J., J Youssef, G., A Olsson, C. and P Mattick, R. (2018). Cohort Profile: The Triple B Pregnancy Cohort Study: A longitudinal study of the relationship between alcohol, tobacco and other substance use during pregnancy and the health and well-being of Australian children and families. International Journal of Epidemiology, 47(1): 26-27m. doi: 10.1093/ije/dyx126
Are data available to others outside study team? Yes, with formal approval from study investigators only
Study focus (e.g. social development) Effects of substance use (alcohol, tobacco, illicit drugs) during pregnancy by women and partners on infant development and family functioning.
Sampling frame Women attending antenatal services attached to major hospitals, and specialist drug and alcohol antenatal services, in New South Wales and Western Australia (Australia).
Study type (e.g. randomised control trial, cohort, case-control) Longitudinal pre-birth cohort
Year commenced 2009
Ongoing recruitment? No
Commencement sample (N) 1,623 families (1534 mothers general antenatal clinics / 89 mothers specialist drug and alcohol antenatal clinics)
Intergenerational (e.g. offspring)? No
Imaging (e.g. fMRI, ultrasound, retinal photograph)? No
Linkage (e.g. BioGrid, VPDC, NAPLAN, Medicare)? No
Biosamples (e.g. buccal, blood, hair)? Buccal
Ethics approvals or requirements (e.g. specific, extended, unspecified, other)? This project only (Specific consent)
Future research related to this project (Extended consent)
Year Age (mean, range) Eligible sample (not deceased, not withdrawn)
2009-2013 Prenatal – Trimester 1 1,621 families
(1533 mothers general antenatal clinics / 88 mothers specialist drug and alcohol antenatal clinics)
2009-2013 Prenatal – Trimester 2 1596 families
(1511 mothers general antenatal clinics / 85 mothers specialist drug and alcohol antenatal clinics)
2009-2013 Prenatal – Trimester 3 1579 families
(1498 mothers; 824 partners general antenatal clinics / 81 mothers specialist drug and alcohol antenatal clinics)
2009-2013 Birth 1479 families
(1414 mothers; 1453 offspring; 1376 singletons, 37 twin pairs, 1 set of triplets general antenatal clinics / 65 mothers; 65 offspring, all singletons specialist drug and alcohol antenatal clinics)
2009-2013 8 weeks of age 1460 families
(1399 mothers; 685 partners*; 1436 infant offspring general antenatal clinics / 61 mothers and infant offspring specialist drug and alcohol antenatal clinics)
*The 8-week follow-up interview for partners was introduced after the pilot study. As such, 8-week data were unavailable for 60
participating partners, as it was not offered.
2010-2014 12 months of age ** families
1289 mothers; 711 partners; 1324 infant offspring general antenatal clinics / 48 mothers; 48 infant offspring specialist drug and alcohol antenatal clinics
**In some families, only infants were assessed at 12 months.

Triple B Scientific Director

Dr Delyse Hutchinson

Ph: +61 425 218 628
Email: delyse.hutchinson@deakin.edu.au

NHMRC Principal Research Fellow

Professor Richard Mattick

Ph:+61 2 9385 0333
Email: r.mattick@unsw.edu.au