It is generally believed that common adult onset disorders (particularly cardiovascular and respiratory diseases) begin in early life, possibly even before birth. Children born following the use of assisted reproductive technologies (ART) might be in a specific risk category because of the techniques used to enable successful ART/pregnancies. However, there are very few studies on adults born following ART.

The 2009-2011 retrospective cohort study, “Comparison of health and development of young adults born with and without assisted conception”, is the largest in-depth study anywhere in the world of people aged 18 years and over who were conceived with ART. The aim of the study was to compare the physical and mental health, educational achievements, and social development of young adults conceived with and without ART. Telephone interviews were conducted with 1524 mothers (reporting on 1573 offspring), and 1096 young adults.

The young adults that participated in the 2009 – 2011 telephone interviews have been invited to take part in the 2016-2017 CHART (Clinical review of the Health of 22-33 year olds conceived with and without Assisted Reproductive Technologies) Study. CHART is a clinical review investigating the respiratory, cardiac and metabolic health, and general wellbeing of the participants. Recruitment began in June 2016.



Wave IYAGS (telephone interview) CHART (clinical review)
Age Mothers: 37 – 71 years; Offspring: 18 – 28 years Offspring: 22-33 years
Year 2009 – 2011 2014 (pilot)
2016-2017 (full study)
# ART: 656 mothers reporting on 705 offspring; 547 offspring reports
Non-ART: 868 mothers reporting on 868 offspring; 549 offspring reports
ART offspring: 540
Non-ART offspring: 532
Time period(s) covered Conception to
first year of life
Before school
(~1-5 years)
Primary school
(~6-13 years)
Secondary school
(~13-18 years)
Young
adulthood
Young
adulthood
Identifiers and miscellaneous
Allergies
Anthropometrics
Behavioural problems
Birth
Cardiovascular health
Condition specific information
Demographics
Education and childcare
General health
Hearing
Imaging
Medications and supplements
Mental health
Neurocognitive development
Nutrition
Parenting
Physical activity and lifestyle
Puberty
Relationships
Reproductive health and pregnancy
Resilience and wellbeing
Respiratory health
Sleep
Speech, language and literacy
Substance use
Young adult transitions
Bioanalyses and omics
Biosamples
Linkage to other database(s)

Study Summary
Study name Comparison of health and development of young adults born with and without assisted conception
Study abbreviation IYAGS
Current principal investigator/s Professor Jane Halliday
Current project manager N/A (project completed in 2011)
Primary Institution Murdoch Childrens Research Institute
Collaborating Institution/s Royal Womens Hospital / Melbourne IVF
Victorian Perinatal Data Collection Unit (VPDCU)
Epworth Hospital / Monash IVF
Major funding sources National Health and Medical Research Council
Jack Brockhoff Foundation
Key reference for study (published study protocol) Wilson, C., Hammarberg, K., Bruinsma, F., Berg, T., Amor, D., Sanson, A., Fisher, J.R. and Halliday, J. (2013).
Health and development of ART conceived young adults: a study protocol for the follow-up of a cohort. Reprod Health, 10: 15.  doi: 10.1186/1742-4755-10-15
Are data available to others outside study team? No
Study focus (e.g. social development) Health and development of young adults born with and without assisted conception
Sampling frame ART Mothers – traced from clinic database
Non-ART Mothers – population-based controls recruited by random digit dialling
ART and non-ART Young Adults – approached with maternal consent
Study type (e.g. randomised control trial, cohort, case-control) Retrospective cohort study (case/control)
Year commenced 2008 (recruitment and data collection commenced in 2009)
Ongoing recruitment? No
Commencement sample (N) ART: 656 mothers reporting on 705 offspring; 547 offspring reports
Non-ART: 868 mothers reporting on 868 offspring; 549 offspring reports
Intergenerational (e.g. offspring)? No
Imaging (e.g. fMRI, ultrasound, retinal photograph)? No
Linkage (e.g. BioGrid, VPDC, NAPLAN, Medicare)? No
Biosamples (e.g. buccal, blood, hair)? No
Ethics approvals or requirements (e.g. specific, extended, unspecified, other)? This project only (Specific consent)
Wave Year Age (mean, range) Eligible sample (not deceased, not withdrawn)
IYAGS (telephone interview) 2009-2011 18-28 years (offspring) 656 IVF mothers and 547 offspring
868 non-IVF mothers and 549 offspring
CHART (clinical review) 2014, 2016-2017 22-33 years Recruitment ongoing
Study Summary
Study name Clinical review of the Health of 22-33 year olds conceived with and without Assisted Reproductive Technologies
Study abbreviation CHART Study
Current principal investigator/s Professor Jane Halliday
Current project manager Dr Sharon Lewis
Primary Institution Murdoch Childrens Research Institute
Collaborating Institution/s Monash IVF
Melbourne IVF
Hudson Institute of Medical Research
Monash University
Major funding sources National Health and Medical Research Council – full study
Murdoch Childrens Research Institute
Royal Children’s Hospital Foundation – pilot
Monash Research & Education Foundation (MREF) – pilot
Melbourne IVF – pilot
Study website https://www.mcri.edu.au/chart
Are data available to others outside study team? Not at present
Study focus (e.g. social development) Clinical review of respiratory, cardiac and metabolic health
Sampling frame 540 ART conceived and 532 age/sex matched controls who consented to follow up from the 2009 – 2011 telephone interview study
Study type (e.g. randomised control trial, cohort, case-control) Clinical review of participants in a previous study
Year commenced 2014 (pilot) 2016-2017 (full study)
Ongoing recruitment? Yes
Target sample (N) 540 ART conceived adults agreed to be contacted about follow-up studies
532 spontaneously conceived adults agreed to be contacted about follow-up studies
Intergenerational (e.g. offspring)? No
Imaging (e.g. fMRI, ultrasound, retinal photograph)? Retinal imaging
Ultrasound
Linkage (e.g. BioGrid, VPDC, NAPLAN, Medicare)? No
Biosamples (e.g. buccal, blood, hair)? Venous blood
Buccal
Newborn screening (Guthrie) card
Ethics approvals or requirements (e.g. specific, extended, unspecified, other)? This project only (Specific consent)
Future research related to this project (Extended consent)
Optional consent included:
– Consent to be contacted about future research projects
– Consent to the sharing of coded data and/or samples with researchers in Australia and/or overseas
– Consent to the storage of blood/DNA samples for use in ethically approved research, related to this project or future projects on the health of young adults conceived via ART
Wave Year Age (mean, range) Eligible sample (not deceased, not withdrawn)
IYAGS (telephone interview) 2009-2011 18-28 years (offspring) 656 IVF mothers and 547 offspring
868 non-IVF mothers and 549 offspring
CHART (clinical review) 2014, 2016-2017 22-33 years Recruitment ongoing

Principal Investigator

Professor Jane Halliday

Project Manager

Dr Sharon Lewis

Study Contact

Ms Joanne Kennedy (CHART)
Ph: +613 9936 6766
Email: chart.study@mcri.edu.au

Postal Address

Public Health Genetics
Murdoch Childrens Research Institute
50 Flemington Rd
Parkville, VIC 3052