Australian Respiratory Early Surveillance Team for Cystic Fibrosis: Detection of early lung disease in Cystic Fibrosis (AREST CF)

The Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) is a multicentre collaborative research study. Beginning in 2006, it initially focussed on the assessment, treatment and prevention of CF lung disease between 0-6 years of age which aimed to identify key drivers of lung disease, targeting for intervention and prevention of lung damage early on. Whilst continuing to do this, AREST CF has also begun to explore interactions between CF lung health and puberty, mental health, family dynamics, pain, sleep and quality of life in our AREST CF adolescents, now aged 10-18 years. This sub-arm is called, The Next Generation Impact of Cystic Fibrosis.

Study Summary
Study name Australian Respiratory Early Surveillance Team for Cystic Fibrosis: Detection of early lung disease in Cystic Fibrosis
Study abbreviation AREST CF
Current principal investigator/s Sarath Ranganathan
Stephen Stick
Current project manager

Rebecca Langford

Primary Institution/s Murdoch Children’s Research Institute - MCRI
Collaborating Institution/s Telethon Kids Institute - TKI
Major funding source/s National Health and Medical Research Council - NHMRC
Murdoch Children’s Research Institute - MCRI
The Royal Children’s Hospital Foundation - RCHF
Study website https://arestcf.telethonkids.org.au/
Study focus

AREST CF seeks to improve the detection, prevention and treatment of early respiratory disease in young children with cystic fibrosis in order to improve clinical outcomes and quality of life for patients and their families.

Sampling frame

Participants were recruited from the Royal Children’s Hospital (Melbourne) or the Princess Margaret Hospital for Children (Perth) (cases and bronchoscopy/BAL controls); from hospital outpatient and inpatient appointments

Primary study type Case-control
Year commenced

2004

Is this study ongoing? Yes - the study is ongoing
Ongoing recruitment? Yes
Sample size (N)

494 CF Cases (204 from Melbourne), 432 Controls (71 from Melbourne) as of December 2021

Survey data available? Yes
Imaging data available? Yes
Linkage to administrative dataset/s? No, no consent to link to administrative dataset(s) obtained
Biosamples available? Yes
Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? Yes
Are there any costs associated with data/sample access for approved requests? There are usually no costs associated with access
Broadest type of participant consent available Unspecified consent (can be used for any future ethically approved research)
Study Contacts
Principal investigator/s Sarath Ranganathan
Stephen Stick
Project manager

Rebecca Langford

Study Contact

Email: arestCF@telethonkids.org.au
Phone: +61 8 6319 1000
Address: Respiratory and Sleep Medicine Department
Royal Children’s Hospital
Flemington Road, Parkville
Victoria 3052 Australia