Children’s Attention Project (and Neuroimaging of the Children’s Attention Project sub-study) (CAP and NICAP)

The Children’s Attention Project (CAP), commenced in 2011, is a prospective longitudinal study of almost 500 children with and without Attention-Deficit/Hyperactivity Disorder (ADHD) recruited from Grade 1 (6 – 8 years old) classes across socio-economically diverse primary schools in Melbourne, Australia.

The study aims to map the course of ADHD symptoms over time and to identify risk and protective factors associated with differential outcomes. CAP is the first Australian longitudinal study of children with and without ADHD and one of the first community-based longitudinal studies of children that meet the full diagnostic criteria for ADHD recruited in the early primary school years. The study’s examination of a broad range of risk and protective factors and ADHD-related outcomes has the potential to inform novel strategies for intervention and prevention.

The Neuroimaging of the Children’s Attention Project (NICAP) sub-study is a comprehensive longitudinal multimodal neuroimaging study of approximately 200 children with and without ADHD from the CAP. NICAP’s primary aims are to determine how brain structure and function change with age in children with and without ADHD, and whether different trajectories of brain development are associated with variations in outcomes including continuing to meet criteria for ADHD, and academic, cognitive, social and mental health outcomes. Establishing which brain regions are associated with differential clinical outcomes may allow us to improve predictions about the course of ADHD.

Year 2011-2012 2013-2014 2014-2016 2014-2016 2016-2017 2016-2017 2018-2019 2018-2019
Wave 1 (CAP) 2 (CAP) 3 (CAP) 3a (NICAP) 4 (CAP) 4a (NICAP) 5 (CAP) 5a (NICAP)
Age 7 years 8.5 years 10 years 10 years 11.5 years 11.5 years 13 years 13 years
N Total: 497
Cases: 179
Controls: 212
100
Total: 485
Cases: 206
Controls: 174
83
Total: 481
Cases: 167
Controls: 192
80
Total: 122
Cases: 59
Controls: 54
6
Total: 122
Cases: 59
Controls: 54
6
Total: 122
Cases: 59
Controls: 54
6
RELEVANT LIFECOURSE DOMAINS Anthropometrics Anthropometrics
Bioanalyses and omics Bioanalyses and omics Bioanalyses and omics
Biosamples Biosamples
Demographics
Education and childcare
Environmental exposures
Family environment
Health services
Imaging Imaging Imaging
Medications and supplements
Mental health and behaviour problems
Methodology
Neurocognitive development
Other health information
Peer relationships
Pregnancy and birth
Psychosocial wellbeing
Puberty
Sleep Sleep
Speech and language Speech and language
Substance use Substance use Substance use
Temperament and personality
Study Summary
Study name Children’s Attention Project (CAP) including Neuroimaging Sub-study (NICAP)
Study abbreviation CAP and NICAP
Current principal investigator/s Emma Sciberras
Tim Silk
Current project manager

Emma Sciberras

Primary Institution/s Murdoch Children’s Research Institute - MCRI
Collaborating Institution/s Deakin University
La Trobe University
Joondalup Child Development Centre - Joondalup, WA
University of Sydney
Sydney Medical School
Major funding source/s National Health and Medical Research Council - NHMRC
Murdoch Children’s Research Institute - MCRI
Key reference for study
Study focus

To examine a broad range of risk and protective factors and ADHD-related outcomes (including mental health, academic, family and child well-being, quality of life) in children with and without Attention-Deficit/Hyperactivity Disorder. Outcomes from this study have the potential to inform novel strategies for intervention and prevention.

Sampling frame

CAP: Grade 1 children with and without ADHD, recruited across 43 socio-economically diverse government primary schools across Melbourne, Australia. All children were in Grade 1, the second year of formal schooling (6-8 years).Potential participants were screened for ADHD symptoms using independent parent and teacher reports on the Conners’ 3 ADHD index (~N = 5260).Children screening positive for ADHD by both parent and teacher report, and a matched sample (gender, school) screening negative, were invited to participate.

NICAP: Recruited from CAP cohort, with equal number of cases and controls.

Primary study type Longitudinal cohort
Year commenced

2011

Is this study ongoing? No - the study is complete
Year study ended 2015
Ongoing recruitment? No
Sample size (N)

Total N = 497
N = 179 Cases
N = 212 Controls
N = 100 'High risk'
N = 6 Not determined

Survey data available? Yes
Imaging data available? Yes
Linkage to administrative dataset/s? Yes, linkage to (at least one) administrative dataset completed
Biosamples available? Yes
Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? Yes
Are there any costs associated with data/sample access for approved requests? There are usually no costs associated with access
Broadest type of participant consent available Extended consent (can be used for future ethically approved research related to this project)
Wave Year Age Sample size (N)
1 (CAP) 2011-2012 7 years N(Total)=497
N(Cases)=179
N(Controls)=212
N()=100
2 (CAP) 2013-2014 8.5 years N(Total)=485
N(Cases)=206
N(Controls)=174
N()=83
3 (CAP) 2014-2016 10 years N(Total)=481
N(Cases)=167
N(Controls)=192
N()=80
3a (NICAP) 2014-2016 10 years N(Total)=122
N(Cases)=59
N(Controls)=54
N()=6
4 (CAP) 2016-2017 11.5 years
4a (NICAP) 2016-2017 11.5 years N(Total)=122
N(Cases)=59
N(Controls)=54
N()=6
5 (CAP) 2018-2019 13 years
5a (NICAP) 2018-2019 13 years N(Total)=122
N(Cases)=59
N(Controls)=54
N()=6
Study Contacts
Principal investigator/s Emma Sciberras
Tim Silk
Project manager

Emma Sciberras

Study Contact

Phone, +613 8341 6363
Email: childrensattentionproject@mcri.edu.au
Address: Children’s Attention Project
Murdoch Children's Research Institute,
Royal Children’s Hospital
Flemington Road, Parkville
Victoria 3052 Australia