The COVID Immune study aims to investigate whether pre-COVID immune phenotypes and biomarkers predict susceptibility to and severity of SARS-CoV-2 infection in extant longitudinal LifeCourse population cohorts of children aged 1 to 24 years and their household. In addition, there is an opportunity to further understand the clinical features, natural history and long-term effects of SARS-CoV-2 infection on immunological and other biomarkers; and the psychosocial impacts of SARS-CoV-2 and its management.



Study Summary
Study name COVID Immune: Predictors of infection and clinical severity with SARS-CoV-2 in extant longitudinal LifeCourse population cohorts of children/young adults and their household/family contacts
Current principal investigator/s Prof David Burgner (Co – Study Principal Investigator)
A/Prof Kirsten Perrett (Co – Study Principal Investigator)
Current project manager Ms Megan Mathers
Primary Institution Murdoch Children’s Research Institute
Major funding sources Rio Tinto
Department of Health and Human Services, the Victor Chiodo Foundation, and Morgan Stanley (Psychosocial aspects)
Are data available to others outside study team? Certain data may be available upon Investigator agreement only
Study focus (e.g. social development) To investigate predictors of infection and clinical severity with SARS-CoV-2 in extant longitudinal LifeCourse population cohorts of children aged 1 to 24 years and their household.
Sampling frame Children/young adults aged 1 to 24 years from each of 4 established cohorts with existing pre-pandemic immune biospecimens (including PBMCs and/or plasma)
Children/young adult ages range from: 1 to 5 years of age (Vitality), 5 to 6 years of age (MIS BAIR), 10 to 14 years (HealthNuts) and 15 to 24 years (SchoolNuts)
Study type (e.g. randomised control trial, cohort, case-control) Longitudinal cohort study
Year commenced 2020
Ongoing recruitment? No
Commencement sample (N) 1172
Intergenerational (e.g. offspring)? No
Imaging (e.g. fMRI, ultrasound, retinal photograph)? No
Linkage (e.g. BioGrid, VPDC, NAPLAN, Medicare)? No
Biosamples (e.g. buccal, blood, hair)? Blood
Ethics approvals or requirements (e.g. specific, extended, unspecified, other)? Specific consent for psychosocial questionnaire data, unspecified consent for blood samples to be used in future ethically approved projects related to infection, allergy, immune responses and child health

Principal Investigators

Prof David Burgner

A/Prof Kirsten Perrett

Project Manager

Ms Megan Mathers

Study Contact

(03) 9936 6029
covid.immune@mcri.edu.au

Postal Address

Murdoch Children’s Research Institute
The Royal Children’s Hospital, 50 Flemington Road
Parkville, Victoria 3052 Australia