Generation Victorian (GenV)
Generation Victorian (GenV) aims to create large, parallel whole-of-state birth and parent cohorts for discovery and interventional research. GenV is open to all babies born in Victoria, Australia, and their parents over two years from mid-2021. Follow up blends study-collected, study-enhanced and linked data and biosamples. GenV is designed to address physical and mental health, and social issues experienced during pregnancy and childhood, as well as the antecedents of a wide range of diseases of ageing. It seeks to generate translatable evidence (prediction, prevention, treatments, services) to improve future wellbeing and reduce the future disease burden of children and adults.
Learn more about GenV at genv.org.au/for-researchers/
| Study Summary | |
|---|---|
| Study name | Generation Victoria |
| Study abbreviation | GenV |
| Current principal investigator/s |
Melissa Wake Richard Saffery Sharon Goldfeld Natasha Zaritski |
| Current project manager |
Vanda Tedesco: Program Manager |
| Primary Institution/s |
Murdoch Children’s Research Institute - MCRI
|
| Collaborating Institution/s |
The Royal Children’s Hospital - RCH
The University of Melbourne, Department of Paediatrics - UoM The Victorian Government - DHHS Cross-sectoral coalition of partners – see https://genv.org.au/about-genv/supporters-and-partners/ |
| Major funding source/s |
Paul Ramsay Foundation - PRF
Victorian State Government Murdoch Children’s Research Institute - MCRI The Royal Children’s Hospital Foundation - RCHF |
| Study website | https://genv.org.au/ https://www.mcri.edu.au/genv |
| Study focus |
GenV is conceptualised as very large birth and parent cohorts, open to all babies born in the state of Victoria over a two-year period and their parents. It will be multi-purpose, supporting observational, interventional, health services and policy research within the same cohort. It is designed to address physical and mental health and social issues experienced during childhood, as well as childhood and adult antecedents of health or disease during ageing. It seeks to generate translatable evidence (prediction, prevention, treatments, services) to improve future wellbeing and reduce the future disease burden of all children and adults. |
| Sampling frame |
All Victorian newborns delivered over a 2-year period and their parents. Vanguard recruitment commenced at Joan Kirner Women & Children’s at Sunshine Hospital in December 2020. State-wide recruitment begins at other Victorian birthing services in mid-2021. |
| Primary study type | Longitudinal cohort |
| Primary participant (at recruitment) | Index child |
| Year commenced |
2021 |
| Is this study ongoing? | Yes - the study is ongoing |
| Ongoing recruitment? | Yes |
| Sample size (N) |
Target: approximately 150,000 newborns and their parents |
| Survey data available? | Yes |
| Imaging data available? | No |
| Linkage to administrative dataset/s? | Yes, linkage to (at least one) administrative dataset underway |
| Biosamples available? | Yes |
| Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? | Yes |
| Are there any costs associated with data/sample access for approved requests? | There are usually no costs associated with access |
| Broadest type of participant consent available |
Unspecified consent (can be used for any future ethically approved research) |
2022
Hu YJ, Fedyukova A, Wang J, Said JM, Thomas N, Noble E, Cheong JLY, Karanatsios B, Goldfeld S, Wake M. (2022). Improving Cohort-Hospital Matching Accuracy through Standardization and Validation of Participant Identifiable Information Children, 9(12), 1916. DOI: 10.3390/children9121916
2021
Hu YJ, Wake M, Clifford S, Said J. (2021). 1059Innovative epidemiological methods in a whole-of-state cohort of children and parents: Generation Victoria (GenV) International Journal of Epidemiology, 50(Supplement_1), dyab168.290-. DOI: 10.1093/ije/dyab168.290
Musgrove E, Gasparini L, McBain K, Clifford SA, Carter SA, Teede H, Wake M. (2021). Synthesizing Core Outcome Sets for outcomes research in cohort studies: a systematic review Pediatric Research, 92(4), 936 - 945. DOI: 10.1038/s41390-021-01801-2
Nkyekyer J, Clifford SA, Mensah FK, Wang Y, Chiu L, Wake M. (2021). Maximizing Participant Engagement, Participation, and Retention in Cohort Studies Using Digital Methods: Rapid Review to Inform the Next Generation of Very Large Birth Cohorts Journal of Medical Internet Research, 23(5), e23499. DOI: 10.2196/23499
Sung V, Williams K, Perlow E, Hu YJ, Ahern S, Said JM, Karanatsios B, Hopper JL, McNeil JJ, Donnan L, Goldfeld S, Wake M. (2021). Enhancing Value and Uptake for Whole-Population Cohorts of Children and Parents: Methods to Integrate Registries into the Generation Victoria Cohort Children, 8(4), 285. DOI: 10.3390/children8040285
Wang J, Hu YJ, Clifford S, Goldfeld S, Wake M. (2021). Selecting life course frameworks to guide and communicate large new cohort studies: Generation Victoria (GenV) case study Journal of Developmental Origins of Health and Disease, 12(6), 829 - 848. DOI: 10.1017/s2040174420001245
2020
Nkyekyer J, Clifford SA, Mensah FK, Wang Y, Chiu L, Wake M. (2020). Maximizing Participant Engagement, Participation, and Retention in Cohort Studies Using Digital Methods: Rapid Review to Inform the Next Generation of Very Large Birth Cohorts (Preprint) . DOI: 10.2196/preprints.23499
| Study Contacts | |
|---|---|
| Principal investigator/s |
Melissa Wake Richard Saffery Sharon Goldfeld Natasha Zaritski |
| Project manager |
Vanda Tedesco: Program Manager |
| Study Contact |
Email: GenVHQ@mcri.edu.au |