International Childhood Cancer Cohort Consortium (I4C)

The International Childhood Cancer Cohort Consortium (I4C) is an innovative alliance that possibly provides the greatest opportunity for finding a preventable cause of childhood cancer. I4C aims to examine associations between environmental exposures and the incidence of childhood cancers by pooling prospective population data from one million pregnant mothers and their babies. Around the world, several large infant/child prospective studies have been launched to examine environmental and biological determinants of common diseases. However, the rarity of virtually all forms of childhood cancer prevent even large cohort studies from examining the possible relationship of common exposures with common types of childhood cancer due to inadequate sample size.

The Murdoch Children’s Research Institute has had a major role in the study concept and planning for I4C, and is functioning as the I4C International Data Coordinating Centre.

Study Summary
Study name International Childhood Cancer Cohort Consortium
Study abbreviation I4C
Current principal investigator/s Terry Dwyer
Current project manager

Gabriella Tikellis

Primary Institution/s Murdoch Children’s Research Institute - MCRI
The George Institute for Global Health
Collaborating Institution/s For a comprehensive list of collaborating institutions, view the Cohort Profile
Major funding source/s National Children's Study
National Institutes of Health - NIH
Children's Cancer Foundation
International Agency for Research on Cancer - IARC
Rotary Club of North Brighton
Tour de Cure
Study website
Key reference for study Brown, R.C., Dwyer, T., Kasten, C., Krotoski, D., Li, Z., Linet, M.S., Olsen, J., Scheidt, P. and Winn, D.M.; International Childhood Cancer Cohort Consortium (I4C). (2007). Cohort profile: the International Childhood Cancer Cohort Consortium (I4C). International Journal of Epidemiology 36(4): 724-30
Study focus

To identify causal risk factors and mechanisms involved in the development of childhood cancers by examining associations between environmental exposures and the incidence of childhood cancers. Pooled prospective population data from over one million mothers and their babies make up this consortium, providing an extaordinary opportunity for exploring the preventable causes of childhood cancer.

Sampling frame

Large population-based longitudinal birth cohorts of greater than 2000 participants with environmental measures in domains of interest for childhood cancers and the possibility of following children for childhood cancer.

Primary study type Databank / Biobank
Primary participant (at recruitment) Index child
Year commenced


Is this study ongoing? Yes - the study is ongoing
Ongoing recruitment? Yes
Sample size (N)

381,860 mother and child pairs as of June 2016, including 671 cases of childhood cancer (198 leukaemia)

Survey data available? Yes
Imaging data available? No
Linkage to administrative dataset/s? Yes, linkage to (at least one) administrative dataset completed
Biosamples available? Yes
Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? Yes
Are there any costs associated with data/sample access for approved requests? There are usually no costs associated with access
Broadest type of participant consent available Unspecified consent (can be used for any future ethically approved research)
Study Contacts
Principal investigator/s Terry Dwyer
Project manager

Gabriella Tikellis

Study Contact

Terry Dwyer