International Childhood Cancer Cohort Consortium (I4C)
The International Childhood Cancer Cohort Consortium (I4C) is an innovative alliance that possibly provides the greatest opportunity for finding a preventable cause of childhood cancer. I4C aims to examine associations between environmental exposures and the incidence of childhood cancers by pooling prospective population data from one million pregnant mothers and their babies. Around the world, several large infant/child prospective studies have been launched to examine environmental and biological determinants of common diseases. However, the rarity of virtually all forms of childhood cancer prevent even large cohort studies from examining the possible relationship of common exposures with common types of childhood cancer due to inadequate sample size.
The Murdoch Children’s Research Institute has had a major role in the study concept and planning for I4C, and is functioning as the I4C International Data Coordinating Centre.
|Study name||International Childhood Cancer Cohort Consortium|
|Current principal investigator/s||
|Current project manager||
Murdoch Children’s Research Institute - MCRI
The George Institute for Global Health
For a comprehensive list of collaborating institutions, view the Cohort Profile
|Major funding source/s||
National Children's Study
National Institutes of Health - NIH
Children's Cancer Foundation
International Agency for Research on Cancer - IARC
Rotary Club of North Brighton
Tour de Cure
|Key reference for study||Brown, R.C., Dwyer, T., Kasten, C., Krotoski, D., Li, Z., Linet, M.S., Olsen, J., Scheidt, P. and Winn, D.M.; International Childhood Cancer Cohort Consortium (I4C). (2007). Cohort profile: the International Childhood Cancer Cohort Consortium (I4C). International Journal of Epidemiology 36(4): 724-30|
To identify causal risk factors and mechanisms involved in the development of childhood cancers by examining associations between environmental exposures and the incidence of childhood cancers. Pooled prospective population data from over one million mothers and their babies make up this consortium, providing an extaordinary opportunity for exploring the preventable causes of childhood cancer.
Large population-based longitudinal birth cohorts of greater than 2000 participants with environmental measures in domains of interest for childhood cancers and the possibility of following children for childhood cancer.
|Primary study type||Databank / Biobank|
|Primary participant (at recruitment)||Index child|
|Is this study ongoing?||Yes - the study is ongoing|
|Sample size (N)||
381,860 mother and child pairs as of June 2016, including 671 cases of childhood cancer (198 leukaemia)
|Survey data available?||Yes|
|Imaging data available?||No|
|Linkage to administrative dataset/s?||Yes, linkage to (at least one) administrative dataset completed|
|Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes?||Yes|
|Are there any costs associated with data/sample access for approved requests?||There are usually no costs associated with access|
|Broadest type of participant consent available||
Unspecified consent (can be used for any future ethically approved research)