LifeCourse A Melbourne Children's Research Initiative

MIS BAIR: Allergies

Relevant LifeCourse Constructs	Year	2013-2016	2013-2016	2013-2016	2013-2016	2013-2016	2014-2017	2014-2017	2014-2018	2018	2015-2018	2015-2018	2016-2019	2016-2019	2017-2020	2017-2020	2018-2021	2018-2021	2021	2020	2021	2022	2022	2022	2022	2022	2022
	Phase	Recruitment (pre-birth)	Randomisation/birth	Discharge from hospital	7 days post randomisation	3 months	6 months	9 months	12 months	End Part 1	18 months	24 months	30 months	36 months	42 months	48 months	54 months	60 months	End Part 2	COVID Immune: Baseline	COVID Immune: 12mth follow-up	COSI BAIR: Visit 1	COSI BAIR: Visit 1 +7 days	COSI BAIR: Visit 2	COSI BAIR: Visit 2 + 7 days	COSI BAIR: Visit 2 + 28 days	COSI BAIR: Visit 2 + 182 days
	Age	Pre-birth	Birth	Birth	Early infancy	3 months	6 months	9 months	12 months	End Part 1	18 months	24 months	30 months	36 months	42 months	48 months	54 months	60 months	End Part 2	5-6 years	End COVID Immune	5-11 years	5-11 years	5-11 years	5-11 years	5-11 years	End COSIBAIR
	N	1272 Total 637 BCG 635 no BCG	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Complete	Substudy: 50	Complete	Complete	Complete	Complete	Complete
Allergic reaction management			P:MIS BAIR ^M ¹ P:MIS BAIR ^F ¹ P:MIS BAIR ^Si ¹				P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I		P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I
Allergic rhinitis							P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I		P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I
Allergy testing										O:SPT ^I O:OFC ^I									O:SPT ^I O:OFC ^I
Allergy to substance			P:MIS BAIR ^M ¹ P:MIS BAIR ^F ¹ P:MIS BAIR ^Si ¹				P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I		P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I
Asthma			P:MIS BAIR ^M ¹ P:MIS BAIR ^F ¹ P:MIS BAIR ^Si ¹				P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I		P:MIS BAIR ^I ² P:ISAAC ^I	P:MIS BAIR ^I ² P:ISAAC ^I	P:MIS BAIR ^I ² P:ISAAC ^I	P:MIS BAIR ^I ² P:ISAAC ^I	P:MIS BAIR ^I ² P:ISAAC ^I	P:MIS BAIR ^I ² P:ISAAC ^I	P:MIS BAIR ^I ² P:ISAAC ^I	P:MIS BAIR ^I ² P:ISAAC ^I
Dermatitis										O:SCORAD ^I			O:SCORAD ^I		O:SCORAD ^I
Eczema			P:MIS BAIR ^M ¹ P:MIS BAIR ^F ¹ P:MIS BAIR ^Si ¹				P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I O:SCORAD ^I		P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I O:SCORAD ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I O:SCORAD ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I	P:MIS BAIR ^I ² P:ISAAC ^I P:POEM ^I
Exercise-induced asthma							P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I		P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I	P:ISAAC ^I
Family history of allergy			P:MIS BAIR ^M ¹ P:MIS BAIR ^F ¹ P:MIS BAIR ^Si ¹
Food allergy			P:MIS BAIR ^M ¹ P:MIS BAIR ^F ¹ P:MIS BAIR ^Si ¹				P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I		P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I	P:HNuts ^I
Hay fever			P:MIS BAIR ^M ¹ P:MIS BAIR ^F ¹ P:MIS BAIR ^Si ¹
Impact of allergy			P:MIS BAIR ^M ¹ P:MIS BAIR ^F ¹ P:MIS BAIR ^Si ¹				P:POEM ^I	P:POEM ^I	P:POEM ^I	P:POEM ^I		P:POEM ^I	P:POEM ^I	P:POEM ^I	P:POEM ^I	P:POEM ^I	P:POEM ^I	P:POEM ^I	P:POEM ^I
Wheezing							P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I		P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I	P:BIS ^I P:ISAAC ^I

Featured measurements

BIS: : Barwon Infant Study-devised measure
HNuts: : HealthNuts Study-devised measure
ISAAC: : International Study of Asthma and Allergies in Children
OFC: : Oral Food Challenge
POEM: : Patient-Oriented Eczema Measure
SCORAD: : SCORing Atopic Dermatitis
SPT: : Skin Prick Test - HealthNuts protocol
MIS BAIR: : The Melbourne Infant Study: BCG for Allergy and Infection Reduction Study-devised measure

Notes

Derived from items used in HealthNuts and the Barwon Infant Study (BIS)

Derived from items used in the Barwon Infant Study (BIS) and the International Study of Asthma and Allergies in Children (ISAAC)

Legend

B: = Biosample collected
BA: = Biosample analysis
G: = Grandparent(s) completed questionnaire
L: = Data linkage
N: = Nurse completed questionnaire
O: = Observation or direct assessment
Of: = Offspring completed questionnaire
P: = Parent/guardian completed questionnaire
Pe: = Peer completed questionnaire
R: = Records abstraction
S: = Self (primary participant) completed questionnaire
T: = Teacher completed questionnaire
X: = Other source
X ^F: = Pertains to father
X ^Fam: = Pertains to family
X ^G: = Pertains to grandparent(s)
X ^I: = Pertains to primary participant
X ^IP: = Pertains to partner
X ^M: = Pertains to mother
X ^O: = Pertains to offspring
X ^P: = Pertains to parent/guardian(s)
X ^Pe: = Pertains to peers
X ^Si: = Pertains to sibling(s)
X ^T: = Pertains to teacher(s)
X ^X: = Pertains to other reportees

Metadata presented by LifeCourse provides a crucial first step in understanding the available data across studies. It does not take the place of detailed study documentation, which should always be consulted during design and analysis.