AREST CF: Respiratory health
| Group | CF 0 – 2 years and preschool (3 – 6 years) | Non-CF Bronchoscopy/ BAL | Non-CF lung function preschool | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wave | W1 | W2 | W3 | W4 | W5 | W6 | W7 | W8 | W9 | W10 | N/A | Screening | Visit 1 | Visit 2 | Visit 3 | Visit 4 (optional) |
| Age | 2 – 4 months | 1 year | 2 years | 3 years | 3.5 years | 4 years | 4.5 years | 5 years | 5.5 years | 6 years | 0 – 6 years | 3 – 6 years | 3 – 6 years | Visit 1 + 6 months | Visit 1 + 12 months | Visit 3 + 12 months |
| Year | 2006 – ongoing | 2006 – ongoing | 2006 – ongoing | 2006 – ongoing | 2006 – ongoing | 2006 – ongoing | 2006 – ongoing | 2006 – ongoing | 2006 – ongoing | 2006 – ongoing | 2010 – ongoing | 2014 – ongoing | 2014 – ongoing | 2014 – ongoing | 2014 – ongoing | 2014 – ongoing |
| Respiratory function test 1 | O:RVRTC O:MBW O:PLETH O:TV |
O:RVRTC O:MBW O:PLETH O:TV |
O:RVRTC O:MBW O:PLETH O:TV |
O:FOT O:MBW |
O:FOT O:MBW |
O:FOT O:MBW |
O:FOT O:MBW |
O:FOT O:MBW O:SPIRO |
O:FOT O:MBW O:SPIRO |
O:FOT O:MBW O:SPIRO |
O:FOT O:SBW O:MBW O:SPIRO 2 |
O:FOT O:SBW O:MBW O:SPIRO 2 |
O:FOT O:SBW O:MBW O:SPIRO 2 |
O:FOT O:SBW O:MBW O:SPIRO 2 |
||
| Respiratory tract infection(s) | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | ||||||
| Asthma | P:SDV | P:RSQ | P:RSQ | P:RSQ | P:RSQ | |||||||||||
| Wheezing | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:SDV | P:RSQ | P:RSQ | P:RSQ | P:RSQ | |
| Hay fever | P:SDV | P:RSQ | P:RSQ | P:RSQ | P:RSQ | |||||||||||
| Coughing | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:SDV | P:RSQ | P:RSQ | P:RSQ | P:RSQ | |
| Sputum | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | ||||||
| Bronchoalveolar lavage (BAL) | X | X | X | X | X | X | X | X | X | X | X | |||||
| Reason for BAL | M | M | M | M | M | M | M | M | M | M | M | |||||
| BAL specimen collection | X | X | X | X | X | X | X | X | X | X | X | |||||
| Bronchial brushing specimen collection (optional) |
X | X | X | X | X | X | X | X | X | X | X | |||||
| CT (chest) | O (subset, 2006 – 2010) | O | O (subset, 2006 – 2010) | O | O (subset, 2006 – 2010) | O | O (subset, 2006 – 2010) | |||||||||
| Electronic Impedance Tomography (EIT) (optional) 3 4 |
O | O | O | |||||||||||||
| Hospitalisation(s) for respiratory reasons (e.g. bronciolitis, pneumonia, lower or upper respiratory tract infection) |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
P:SDV | |||||
| Medications (respiratory-related (including inhaled agents), anti-fungals, anti-reflux, other prescriptions) |
P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:SDV | P:RSQ | P:RSQ | P:RSQ | P:RSQ | |
| Visit | Screening/ enrolment | Visit 1A Baseline | Visit 1B | Visit 2 | Visit 3 | Visit 4 | Visit 5A | Visit 5B | Phone interviews (weekly) |
|---|---|---|---|---|---|---|---|---|---|
| Age | (3 m ± 1m) | (4 m ± 1m) | Within 2 weeks of visit 1A | (6 m ± 1m) | (8 m ± 1m) | (10 m ± 1m) | (12 m ± 1m) | Within 2 weeks of visit 5A | Weekly |
| Year | 2013 – 2016 | 2013 – 2016 | 2013 – 2016 | 2013 – 2017 | 2013 – 2017 | 2013 – 2017 | 2014 – 2017 | 2014 – 2017 | 2013 – 2017 |
| Respiratory function test | O:RVRTC 1 O:MBW 1 O:PLETH 1 O:TV 1 |
O:RVRTC 1 O:MBW 1 O:PLETH 1 O:TV 1 |
|||||||
| Bronchoalveolar lavage (BAL) specimen collection |
X 1 | X 1 | |||||||
| CT (chest) | O 1 | ||||||||
| Hospitalisation(s) for respiratory reasons (e.g. bronciolitis, pneumonia, lower or upper respiratory tract infection) |
M | M | M | M | M | M | M |
| Group | CF school age (7 – 9 years) | Non-CF lung function school age | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Wave | W1 | W2 | W3 | W4 | W5 | Screening | Visit 1 | Visit 2 | Visit 3 |
| Age | 7 years | 7.5 years | 8 years | 8.5 years | 9 years | 7 – 9 years | 7 – 9 years | Visit 1 + 6 months | Visit 1 + 12 months |
| Year | 2013 – ongoing | 2013 – ongoing | 2013 – ongoing | 2013 – ongoing | 2013 – ongoing | 2016 – ongoing | 2016 – ongoing | 2016 – ongoing | 2016 – ongoing |
| Respiratory function test 1 | O:SPIRO O:FOT 2 O:SBW 2 O:MBW 2 |
O:SPIRO O:FOT 2 O:SBW 2 O:MBW 2 |
O:SPIRO O:FOT 2 O:SBW 2 O:MBW 2 |
O:SPIRO O:FOT 2 O:SBW 2 O:MBW 2 |
O:SPIRO O:FOT 2 O:SBW 2 O:MBW 2 |
O:SPIRO 2 O:FOT 2 O:SBW 2 O:MBW 2 |
O:SPIRO 2 O:FOT 2 O:SBW 2 O:MBW 2 |
O:SPIRO 2 O:FOT 2 O:SBW 2 O:MBW 2 |
|
| Respiratory tract infection(s) | P:CF RSQ | P:CF RSQ | P:CF RSQ | ||||||
| Asthma | P:RSQ | P:RSQ | P:RSQ | ||||||
| Wheezing | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:RSQ | P:RSQ | P:RSQ | |||
| Hay fever | P:RSQ | P:RSQ | P:RSQ | ||||||
| Coughing | P:CF RSQ | P:CF RSQ | P:CF RSQ | P:RSQ | P:RSQ | P:RSQ | |||
| Sputum | P:CF RSQ | P:CF RSQ | P:CF RSQ | ||||||
| CT (chest) | O | O | O | ||||||
| Induced sputum collection | X | X | X | ||||||
| Hospitalisation(s) for respiratory reasons (e.g. bronciolitis, pneumonia, lower or upper respiratory tract infection) |
P:CF RSQ M |
P:CF RSQ M |
P:CF RSQ M |
||||||
| Medications (respiratory-related (including inhaled agents), anti-fungals, anti-reflux, other prescriptions) |
P:CF RSQ | P:CF RSQ | P:CF RSQ | P:RSQ | P:RSQ | P:RSQ | |||
Featured measurements
CF RSQ: CF Respiratory Symptom QuestionnaireFOT: Forced Oscillation Technique
ISAAC: International Study of Asthma and Allergy in Children adaptation
MBW: Multiple Breath Washout
PLETH: Plethysmography
RSQ: Respiratory Symptom Questionnaire
RVRTC: Raised Volume Rapid abdominal Thoraco-Compression
SBW: Single Breath Washout
SDV: Study Devised Variable
SPIRO: Spirometry
TV: Tidal Volume
Notes
0 – 6 years
The CF RSQ was developed by the AREST CF team and collects information about the child’s health (cough, sputum, respiratory tract infection, admissions, exercise and medications) in the preceding three months.
The RSQ was developed by the AREST CF team for non-CF participants and includes questions adapted from ISAAC.
1 If Pseudomonas aeruginosa is detected via sputum or BAL samples in a preschool (3 – 6 years) CF cohort participant, respiratory function tests (SBW and MBW) are performed
2 Spirometry only performed in children aged 5 and 6 years
3 EIT measured during infant MBW
4 EIT measurements were started in 2017
0 – 1 year sub-study
1 As per the Detecting Early Lung Disease (0 – 6 years) schedule
7 – 9 years
The CF RSQ was developed by the AREST CF team and collects information about the child’s health (cough, sputum, respiratory tract infection, admissions, exercise and medications) in the preceding three months.
The RSQ was developed by the AREST CF team for non-CF participants and includes questions adapted from ISAAC.
1 If Pseudomonas aeruginosa is detected in a school age (7 – 9 years) CF cohort participant, respiratory function tests (SBW and MBW) are performed pre and post eradication.
2 Optional assessments.
Legend
| A | = Administration report abstraction |
| C | = Index child report (reporting on others) |
| L | = Linkage (to other databases) |
| M | = Medical records data abstraction |
| O | = Observation/direct assessment |
| N | = Nurse report |
| P | = Parent/primary caregiver report |
| Pe | = Peer report |
| S | = Self report |
| T | = Teacher report |
| X | = Undefined |
| X BF | = Pertaining to biological father |
| X BM | = Pertaining to biological mother |
| X C | = Pertaining to index child |
| X F | = Pertaining to father |
| X Fam | = Pertaining to family |
| X G | = Pertaining to grandparent(s) |
| X M | = Pertaining to mother |
| X P | = Pertaining to parent(s) |
| X Pa | = Pertaining to partner |
| X Pe | = Pertaining to peers |
| X Pr | = Pertaining to primary caregiver |
| X Si | = Pertaining to sibling(s) |