Childhood Overweight BioRepository of Australia (COBRA)

COBRA (Childhood Overweight BioRepository of Australia) is a comprehensive repository of data and biological samples, established in 2009, from overweight and obese children and their families.

Obesity in early life is associated with many adverse effects on health, including an increased risk of type 2 diabetes (T2DM), heart and liver disease. Unfortunately, to date, traditional methods of research have failed to identify effective prevention and treatment strategies, and large numbers of children and adolescents continue to be at high risk of developing weight-related disease.

By collecting baseline environmental, clinical and anthropometric data, biological samples for genetic, metabolic and hormonal profiles, and incorporating opportunities for longitudinal data collection into the study design, COBRA will enable researchers to better understand the complex interplay between environmental and genetic factors that govern disease risk.

Study Summary
Study name Childhood Overweight BioRepository of Australia
Study abbreviation COBRA
Current principal investigator/s Matt Sabin
Prof David Burgner (MCRI, University of Melbourne)
Richard Saffery
Current project manager

Brooke Harcourt

Primary Institution/s Murdoch Children’s Research Institute - MCRI
Collaborating Institution/s Cincinnati Children’s Hospital Medical Center
Major funding source/s Murdoch Children’s Research Institute - MCRI
The Royal Children’s Hospital Foundation - RCHF
Key reference for study Sabin, M.A., Clemens, S.L., Saffery, R., McCallum, Z., Campbell, M.W., Kiess, W., Crimmins, N.A., Woo, J.G., Leong, G.M., Werther, G.A., Ukoumunne, O.C. and Wake, M. A. (2010). New directions in childhood obesity research: how a comprehensive biorepository will allow better prediction of outcomes. BMC Medical Research Methodology, 10: 100
Study focus

To develop a unique repository of data and biological samples from overweight and obese children and their families, incorporating opportunities for longitudinal data collection into the study design

Sampling frame

Presentation to the specialist weight management service at The Royal Children’s Hospital (Melbourne)

Primary study type Databank / Biobank
Primary participant (at recruitment) Index child
Year commenced

2009

Is this study ongoing? Yes - the study is ongoing
Ongoing recruitment? Yes
Sample size (N)

~500 as of June 2016

Survey data available? Yes
Imaging data available? No
Linkage to administrative dataset/s? No, no consent to link to administrative dataset(s) obtained
Biosamples available? Yes
Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? Yes
Are there any costs associated with data/sample access for approved requests? There are usually no costs associated with access
Broadest type of participant consent available Unspecified consent (can be used for any future ethically approved research)
Phase Year Age Sample size (N)
Baseline 2009-Ongoing 2-18 years IN PROGRESS
Clinic Visit 2009-Ongoing 2-18 years IN PROGRESS
Study Contacts
Principal investigator/s Matt Sabin
Prof David Burgner (MCRI, University of Melbourne)
Richard Saffery
Project manager

Brooke Harcourt

Study Contact

Email: growing.healthy.kids@mcri.edu.au
Phone: (03) 9936 6184
Address: COBRA Coordinator – Weight Management Service
Level 5 East
C/O Royal Children’s Hospital
Flemington Road, Parkville
Victoria 3052 Australia