Assisted Reproductive Technologies Studies (ART)
The 2009-2011 retrospective cohort study, “Comparison of health and development of young adults born with and without assisted conception”, is the largest in-depth study anywhere in the world of people aged 18 years and over who were conceived with ART. The aim of the study was to compare the physical and mental health, educational achievements, and social development of young adults conceived with and without ART. Telephone interviews were conducted with 1524 mothers (reporting on 1573 offspring), and 1096 young adults.
The young adults that participated in the 2009 – 2011 telephone interviews have been invited to take part in the 2016-2017 CHART (Clinical review of the Health of 22-35 year olds conceived with and without Assisted Reproductive Technologies) Study. CHART is a clinical review investigating the respiratory, cardiac and metabolic health, and general wellbeing of the participants. Recruitment began in June 2016.
| Year | 2009-2011 | 2009-2011 |
|---|---|---|
| Phase | Retrospective telephone interview - Mother | Retrospective telephone interview - Offspring |
| Age | 18-29 years | 18-29 years |
| N | 656 (ART); 868 (Non-ART) | 547 (ART); 549 (Non-ART) |
| RELEVANT LIFECOURSE DOMAINS | Allergies | |
| Anthropometrics | ||
| Community environment | ||
| Demographics | ||
| Education and childcare | ||
| Family environment | ||
| Health services | ||
| Hearing | ||
| Medications and supplements | ||
| Mental health and behaviour problems | ||
| Methodology | ||
| Neurocognitive development | ||
| Nutrition | ||
| Other health information | ||
| Peer relationships | ||
| Physical activity | ||
| Pregnancy and birth | ||
| Psychosocial wellbeing | ||
| Puberty | ||
| Respiratory health | ||
| Romantic relationships | ||
| Sleep | ||
| Speech and language | ||
| Year | 2014-2017 |
|---|---|
| Phase | Clinical Review |
| Age | 22-35 years |
| N | 540 (ART); 532 (Non-ART) |
| RELEVANT LIFECOURSE DOMAINS | Allergies |
| Anthropometrics | |
| Bioanalyses and omics | |
| Biosamples | |
| Cardiovascular health | |
| Community environment | |
| Demographics | |
| Education and childcare | |
| Family environment | |
| Health services | |
| Imaging | |
| Mental health and behaviour problems | |
| Methodology | |
| Nutrition | |
| Other health information | |
| Physical activity | |
| Psychosocial wellbeing | |
| Respiratory health | |
| Romantic relationships | |
| Sleep | |
| Substance use |
| Study Summary | |
|---|---|
| Study name | Comparison of health and development of young adults born with and without assisted conception |
| Study abbreviation | ART-IYAGS |
| Current principal investigator/s |
Jane Halliday |
| Current project manager |
Sharon Lewis |
| Primary Institution/s |
Murdoch Children’s Research Institute - MCRI
|
| Collaborating Institution/s |
Royal Womens Hospital / Melbourne IVF Victorian Perinatal Data Collection Unit - VPDCU Epworth Hospital / Monash IVF |
| Major funding source/s |
National Health and Medical Research Council - NHMRC
The Jack Brockhoff Foundation |
| Key reference for study | Wilson, C., Hammarberg, K., Bruinsma, F., Berg, T., Amor, D., Sanson, A., Fisher, J.R. and Halliday, J. (2013). Health and development of ART conceived young adults: a study protocol for the follow-up of a cohort. Reprod Health, 10: 15. doi: 10.1186/1742-4755-10-15 |
| Study focus |
Health and development of young adults born with and without assisted conception, via interviews and clinical review of respiratory, cardiac and metabolic health |
| Sampling frame |
Mothers using assisted conception were traced through clinic databases (Melbourne IVF and Monash IVF in Victoria, Australia), their young adult offspring were contacted with permission from their mother. Population-based controls were recruited by random digit dialling (households in Victoria, Australia). |
| Primary study type | Case-control |
| Primary participant (at recruitment) | Index child |
| Year commenced |
2008 |
| Is this study ongoing? | No - the study is complete |
| Year study ended | 2017 |
| Ongoing recruitment? | No |
| Sample size (N) |
656 IVF mothers and 547 offspring |
| Survey data available? | Yes |
| Imaging data available? | No |
| Linkage to administrative dataset/s? | No, no consent to link to administrative dataset(s) obtained |
| Biosamples available? | No |
| Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? | Yes |
| Are there any costs associated with data/sample access for approved requests? | There are usually no costs associated with access |
| Broadest type of participant consent available |
Specific consent (can be used for this project only) |
| Study Summary | |
|---|---|
| Study name | Clinical review of the Health of 22-35 year olds conceived with and without Assisted Reproductive Technologies |
| Study abbreviation | ART-CHART |
| Current principal investigator/s |
Jane Halliday |
| Current project manager |
Sharon Lewis |
| Primary Institution/s |
Murdoch Children’s Research Institute - MCRI
|
| Collaborating Institution/s |
Monash IVF Melbourne IVF Hudson Institute of Medical Research Monash University |
| Major funding source/s |
National Health and Medical Research Council - NHMRC
Murdoch Children’s Research Institute - MCRI The Royal Children’s Hospital Foundation - RCHF Monash Research & Education Foundation - MREF Melbourne IVF |
| Study website | https://www.mcri.edu.au/research/projects/assisted-reproductive-technologies |
| Key reference for study | Lewis, S., Kennedy, J., Burgner, D., McLachlan, R., Ranganathan, S., Hammarberg, K., Saffery, R., Amor, D.J., Cheung, M.M.H., Doyle, L.W., Juonala, M., Donath, S., McBain, J. and Halliday, J. (2017). Clinical review of 24-35 year olds conceived with and without in vitro fertilization: study protocol. Reprod Health, 14(1): 117. doi: 10.1186/s12978-017-0377-3 |
| Study focus |
Health and development of young adults born with and without assisted conception, via interviews and clinical review of respiratory, cardiac and metabolic health |
| Sampling frame |
540 ART conceived and 532 age and sex matched controls who consented to follow up from the 2009 – 2011 telephone interview study |
| Primary study type | Case-control |
| Primary participant (at recruitment) | Index child |
| Year commenced |
2014 |
| Is this study ongoing? | No - the study is complete |
| Year study ended | 2017 |
| Ongoing recruitment? | No |
| Sample size (N) |
540 ART conceived adults agreed to be contacted about follow-up studies |
| Survey data available? | Yes |
| Imaging data available? | Yes |
| Linkage to administrative dataset/s? | No, no consent to link to administrative dataset(s) obtained |
| Biosamples available? | Yes |
| Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? | Yes |
| Are there any costs associated with data/sample access for approved requests? | There are usually no costs associated with access |
| Broadest type of participant consent available |
Extended consent (can be used for future ethically approved research related to this project) |
| Study Contacts | |
|---|---|
| Principal investigator/s |
Jane Halliday |
| Project manager |
Sharon Lewis |
| Study Contact |
Phone: +613 9936 6766 |
| Study Contacts | |
|---|---|
| Principal investigator/s |
Jane Halliday |
| Project manager |
Sharon Lewis |
| Study Contact |
Phone: +613 9936 6766 |