Assisted Reproductive Technologies Studies (ART)

The 2009-2011 retrospective cohort study, “Comparison of health and development of young adults born with and without assisted conception”, is the largest in-depth study anywhere in the world of people aged 18 years and over who were conceived with ART. The aim of the study was to compare the physical and mental health, educational achievements, and social development of young adults conceived with and without ART. Telephone interviews were conducted with 1524 mothers (reporting on 1573 offspring), and 1096 young adults.

The young adults that participated in the 2009 – 2011 telephone interviews have been invited to take part in the 2016-2017 CHART (Clinical review of the Health of 22-35 year olds conceived with and without Assisted Reproductive Technologies) Study. CHART is a clinical review investigating the respiratory, cardiac and metabolic health, and general wellbeing of the participants. Recruitment began in June 2016.

Study Summary
Study name Comparison of health and development of young adults born with and without assisted conception
Study abbreviation ART-IYAGS
Current principal investigator/s Jane Halliday
Current project manager

Sharon Lewis

Primary Institution/s Murdoch Children’s Research Institute - MCRI
Collaborating Institution/s Royal Womens Hospital / Melbourne IVF
Victorian Perinatal Data Collection Unit - VPDCU
Epworth Hospital / Monash IVF
Major funding source/s National Health and Medical Research Council - NHMRC
The Jack Brockhoff Foundation
Key reference for study Wilson, C., Hammarberg, K., Bruinsma, F., Berg, T., Amor, D., Sanson, A., Fisher, J.R. and Halliday, J. (2013). Health and development of ART conceived young adults: a study protocol for the follow-up of a cohort. Reprod Health, 10: 15. doi: 10.1186/1742-4755-10-15
Study focus

Health and development of young adults born with and without assisted conception, via interviews and clinical review of respiratory, cardiac and metabolic health

Sampling frame

Mothers using assisted conception were traced through clinic databases (Melbourne IVF and Monash IVF in Victoria, Australia), their young adult offspring were contacted with permission from their mother. Population-based controls were recruited by random digit dialling (households in Victoria, Australia).

Primary study type Case-control
Primary participant (at recruitment) Index child
Year commenced

2008

Is this study ongoing? No - the study is complete
Year study ended 2017
Ongoing recruitment? No
Sample size (N)

656 IVF mothers and 547 offspring
868 non-IVF mothers and 549 offspring

Survey data available? Yes
Imaging data available? No
Linkage to administrative dataset/s? No, no consent to link to administrative dataset(s) obtained
Biosamples available? No
Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? Yes
Are there any costs associated with data/sample access for approved requests? There are usually no costs associated with access
Broadest type of participant consent available Specific consent (can be used for this project only)
Phase Year Age Sample size (N)
Retrospective telephone interview - Mother 2009-2011 18-29 years 656 (ART); 868 (Non-ART)
Retrospective telephone interview - Offspring 2009-2011 18-29 years 547 (ART); 549 (Non-ART)
Study Summary
Study name Clinical review of the Health of 22-35 year olds conceived with and without Assisted Reproductive Technologies
Study abbreviation ART-CHART
Current principal investigator/s Jane Halliday
Current project manager

Sharon Lewis

Primary Institution/s Murdoch Children’s Research Institute - MCRI
Collaborating Institution/s Monash IVF
Melbourne IVF
Hudson Institute of Medical Research
Monash University
Major funding source/s National Health and Medical Research Council - NHMRC
Murdoch Children’s Research Institute - MCRI
The Royal Children’s Hospital Foundation - RCHF
Monash Research & Education Foundation - MREF
Melbourne IVF
Study website https://www.mcri.edu.au/research/projects/assisted-reproductive-technologies
Key reference for study Lewis, S., Kennedy, J., Burgner, D., McLachlan, R., Ranganathan, S., Hammarberg, K., Saffery, R., Amor, D.J., Cheung, M.M.H., Doyle, L.W., Juonala, M., Donath, S., McBain, J. and Halliday, J. (2017). Clinical review of 24-35 year olds conceived with and without in vitro fertilization: study protocol. Reprod Health, 14(1): 117. doi: 10.1186/s12978-017-0377-3
Study focus

Health and development of young adults born with and without assisted conception, via interviews and clinical review of respiratory, cardiac and metabolic health

Sampling frame

540 ART conceived and 532 age and sex matched controls who consented to follow up from the 2009 – 2011 telephone interview study

Primary study type Case-control
Primary participant (at recruitment) Index child
Year commenced

2014

Is this study ongoing? No - the study is complete
Year study ended 2017
Ongoing recruitment? No
Sample size (N)

540 ART conceived adults agreed to be contacted about follow-up studies
532 spontaneously conceived adults agreed to be contacted about follow-up studies

Survey data available? Yes
Imaging data available? Yes
Linkage to administrative dataset/s? No, no consent to link to administrative dataset(s) obtained
Biosamples available? Yes
Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes? Yes
Are there any costs associated with data/sample access for approved requests? There are usually no costs associated with access
Broadest type of participant consent available Extended consent (can be used for future ethically approved research related to this project)
Phase Year Age Sample size (N)
Clinical Review 2014-2017 22-35 years 540 (ART); 532 (Non-ART)
Study Contacts
Principal investigator/s Jane Halliday
Project manager

Sharon Lewis

Study Contact

Phone: +613 9936 6766
Email: chart.study@mcri.edu.au
Address: Reproductive Epidemiology
Murdoch Children's Research Institute,
Royal Children’s Hospital
Flemington Road, Parkville
Victoria 3052 Australia

Study Contacts
Principal investigator/s Jane Halliday
Project manager

Sharon Lewis

Study Contact

Phone: +613 9936 6766
Email: chart.study@mcri.edu.au
Address: Reproductive Epidemiology
Murdoch Children's Research Institute,
Royal Children’s Hospital
Flemington Road, Parkville
Victoria 3052 Australia