2000 Stories: Victorian Adolescent Health Cohort Study and Victorian Intergenerational Health Cohort Study (2000 Stories)

Study Summary
Study name	Victorian Intergenerational Health Cohort Study
Study abbreviation	VIHCS
Current principal investigator/s	Craig Olsson
Current project manager	Carolina Murphy
Primary Institution/s	Murdoch Children’s Research Institute - MCRI
Collaborating Institution/s	The Royal Children’s Hospital - RCH
Major funding source/s	National Health and Medical Research Council - NHMRC Australian Rotary Health Mental Health of Young Australians Research Grant Colonial Foundation Murdoch Children’s Research Institute - MCRI
Study website	https://www.mcri.edu.au/2000-stories
Key reference for study	Spry, E., Olsson, C. A., Hearps, S., Aarsman, S., Carlin, J. B., Howard, L. M., Moreno-Betancur, M., Romaniuk, H., Doyle, L. W., Brown, S., Borschmann, R., Alway, Y., Coffey, C., & Patton, G. C. (2020). The Victorian Intergenerational Health Cohort Study (VIHCS): Study design of a preconception cohort from parent adolescence to offspring childhood. Paediatric and perinatal epidemiology, 34(1), 86–98. https://doi.org/10.1111/ppe.12602
Study focus	VAHCS explores the extent to which risks that emerge in these transition years of adolescence and young adulthood may predict pregnancy risks, birth outcomes, postnatal maternal mental health and maternal child attachment in the first year of life. VAHCS has now been extended with VIHCS to further follow up offspring in childhood, allowing us to examine the extent to which preconception predictors may predict child and parental outcomes at age 8 years.
Sampling frame	The sample frame comprised all active members of the Victorian Adolescent Health Cohort (VAHCS) who reported having a child between the recruitment phase (2006-2014). 1635 active study members were contacted at six-monthly intervals during the recruitment phase, via email, telephone and text message. Study members were invited to participate if they or their partner was pregnant or had a child born in the past 12 months.
Primary study type	Longitudinal cohort
Year commenced	2006
Is this study ongoing?	Yes - the study is ongoing
Ongoing recruitment?	No
Sample size (N)	1030
Survey data available?	Yes
Imaging data available?	No
Linkage to administrative dataset/s?	Yes, linkage to (at least one) administrative dataset completed
Biosamples available?	Yes
Are data available to others outside study team, with appropriate safeguards and structures in line with the cohort’s ethics and governance processes?	Yes
Are there any costs associated with data/sample access for approved requests?	There are usually no costs associated with access
Broadest type of participant consent available	Unspecified consent (can be used for any future ethically approved research)

2023

Spry EA, Olsson CA, Aarsman SR, Mohamad Husin H, Macdonald JA, Dashti SG, Moreno-Betancur M, Letcher P, Biden EJ, Thomson KC, McAnally H, Greenwood CJ, Middleton M, Hutchinson DM, Carlin JB, Patton GC. (2023). Parental personality and early life ecology: a prospective cohort study from preconception to postpartum. Sci Rep, 13(1), 3332. DOI: 10.1038/s41598-023-29139-1

Thomson KC, Greenwood CJ, Letcher P, Spry EA, Macdonald JA, McAnally HM, Hines LA, Youssef GJ, McIntosh JE, Hutchinson D, Hancox RJ, Patton GC, Olsson CA. (2023). Continuities in maternal substance use from early adolescence to parenthood: findings from the intergenerational cohort consortium. Psychol Med, 53(5), 2136 - 2145. DOI: 10.1017/S0033291721003925

2022

Hutchinson D, Spry EA, Mohamad Husin H, Middleton M, Hearps S, Moreno-Betancur M, Elliott EJ, Ryan J, Olsson CA, Patton GC. (2022). Longitudinal prediction of periconception alcohol use: a 20-year prospective cohort study across adolescence, young adulthood and pregnancy. Addiction, 117(2), 343 - 353. DOI: 10.1111/add.15632

Moran P, Moreno-Betancur M, Coffey C, Spry EA, Patton GC. (2022). Impact of early intervention on the population prevalence of common mental disorders: 20-year prospective study. Br J Psychiatry, 221(3), 558 - 566. DOI: 10.1192/bjp.2022.3

2021

Chan GCK, Becker D, Butterworth P, Hines L, Coffey C, Hall W, Patton G. (2021). Young-adult compared to adolescent onset of regular cannabis use: A 20-year prospective cohort study of later consequences. Drug Alcohol Rev, 40(4), 627 - 636. DOI: 10.1111/dar.13239

Hines LA, Spry EA, Moreno-Betancur M, Mohamad Husin H, Becker D, Middleton M, Craig JM, Doyle LW, Olsson CA, Patton G. (2021). Cannabis and tobacco use prior to pregnancy and subsequent offspring birth outcomes: a 20-year intergenerational prospective cohort study. Sci Rep, 11(1), 16826. DOI: 10.1038/s41598-021-95460-2

Olsson CA, Spry EA, Alway Y, Moreno-Betancur M, Youssef G, Greenwood C, Letcher P, Macdonald JA, McIntosh J, Hutchinson D, Patton GC. (2021). Preconception depression and anxiety symptoms and maternal-infant bonding: a 20-year intergenerational cohort study. Arch Womens Ment Health, 24(3), 513 - 523. DOI: 10.1007/s00737-020-01081-5

Spry EA, Moreno-Betancur M, Middleton M, Howard LM, Brown SJ, Molyneaux E, Greenwood CJ, Letcher P, Macdonald JA, Thomson KC, Biden EJ, Olsson CA, Patton GC. (2021). Preventing postnatal depression: a causal mediation analysis of a 20-year preconception cohort. Philos Trans R Soc Lond B Biol Sci, 376(1827), 20200028. DOI: 10.1098/rstb.2020.0028

2020

Olsson CA, Spry E, Letcher P, McAnally H, Thomson K, Macdonald J, Greenwood C, Youssef G, Romaniuk H, Iosua E, Sligo J, Hutchinson D, McIntosh J, O’Connor M, McGee R, Sanson A, Hancox RJ, Patton GC. (2020). The Australian and New Zealand Intergenerational Cohort Consortium: a study protocol for investigating mental health and well-being across generations Longitudinal and Life Course Studies, 11(2), 267 - 281. DOI: 10.1332/175795920x15792720930280

Spry E, Moreno-Betancur M, Becker D, Romaniuk H, Carlin JB, Molyneaux E, Howard LM, Ryan J, Letcher P, McIntosh J, Macdonald JA, Greenwood CJ, Thomson KC, McAnally H, Hancox R, Hutchinson DM, Youssef GJ, Olsson CA, Patton GC. (2020). Maternal mental health and infant emotional reactivity: a 20-year two-cohort study of preconception and perinatal exposures. Psychol Med, 50(5), 827 - 837. DOI: 10.1017/S0033291719000709

Spry E, Olsson CA, Hearps SJC, Aarsman S, Carlin JB, Howard LM, Moreno-Betancur M, Romaniuk H, Doyle LW, Brown S, Borschmann R, Alway Y, Coffey C, Patton GC. (2020). The Victorian Intergenerational Health Cohort Study (VIHCS): Study design of a preconception cohort from parent adolescence to offspring childhood. Paediatr Perinat Epidemiol, 34(1), 86 - 98. DOI: 10.1111/ppe.12602

Spry EA, Aarsman SR, Youssef GJ, Patton GC, Macdonald JA, Sanson A, Thomson K, Hutchinson DM, Letcher P, Olsson CA. (2020). Maternal and paternal depression and anxiety and offspring infant negative affectivity: A systematic review and meta-analysis Developmental Review, 58, 100934. DOI: 10.1016/j.dr.2020.100934

Spry EA, Wilson CA, Middleton M, Moreno-Betancur M, Doyle LW, Howard LM, Hannan AJ, Wlodek ME, Cheong JL, Hines LA, Coffey C, Brown S, Olsson CA, Patton GC. (2020). Parental mental health before and during pregnancy and offspring birth outcomes: A 20-year preconception cohort of maternal and paternal exposure. EClinicalMedicine, 27, 100564. DOI: 10.1016/j.eclinm.2020.100564

2019

Borschmann R, Molyneaux E, Spry E, Moran P, Howard LM, Macdonald JA, Brown SJ, Moreno-Betancur M, Olsson CA, Patton GC. (2019). Pre-conception self-harm, maternal mental health and mother-infant bonding problems: a 20-year prospective cohort study. Psychol Med, 49(16), 2727 - 2735. DOI: 10.1017/S0033291718003689

2018

Macdonald JA, Youssef GJ, Phillips L, Spry E, Alway Y, Patton GC, Olsson CA. (2018). The parental bonds of adolescent girls and next-generation maternal-infant bonding: findings from the Victorian Intergenerational Health Cohort Study. Arch Womens Ment Health, 21(2), 171 - 180. DOI: 10.1007/s00737-017-0778-x

Patton GC, Olsson CA, Skirbekk V, Saffery R, Wlodek ME, Azzopardi PS, Stonawski M, Rasmussen B, Spry E, Francis K, Bhutta ZA, Kassebaum NJ, Mokdad AH, Murray CJL, Prentice AM, Reavley N, Sheehan P, Sweeny K, Viner RM, Sawyer SM. (2018). Adolescence and the next generation. Nature, 554(7693), 458 - 466. DOI: 10.1038/nature25759

Patton GC, Olsson CA, Skirbekk V, Saffery R, Wlodek ME, Azzopardi PS, Stonawski M, Rasmussen B, Spry E, Francis K, Bhutta ZA, Kassebaum NJ, Mokdad AH, Murray CJL, Prentice AM, Reavley N, Sheehan P, Sweeny K, Viner RM, Sawyer SM. (2018). Publisher Correction: Adolescence and the next generation. Nature, 559(7712), E1. DOI: 10.1038/s41586-018-0069-3

Spry E, Giallo R, Moreno-Betancur M, Macdonald J, Becker D, Borschmann R, Brown S, Patton GC, Olsson CA. (2018). Preconception prediction of expectant fathers' mental health: 20-year cohort study from adolescence. BJPsych Open, 4(2), 58 - 60. DOI: 10.1192/bjo.2017.10

2017

Hudson C, Spry E, Borschmann R, Becker D, Moran P, Olsson C, Coffey C, Romaniuk H, Bayer JK, Patton GC. (2017). Preconception personality disorder and antenatal maternal mental health: A population-based cohort study. J Affect Disord, 209, 169 - 176. DOI: 10.1016/j.jad.2016.11.022

2015

Patton GC, Romaniuk H, Spry E, Coffey C, Olsson C, Doyle LW, Oats J, Hearps S, Carlin JB, Brown S. (2015). Prediction of perinatal depression from adolescence and before conception (VIHCS): 20-year prospective cohort study. Lancet, 386(9996), 875 - 883. DOI: 10.1016/S0140-6736(14)62248-0

2014

Romaniuk H, Patton GC, Carlin JB. (2014). Multiple imputation in a longitudinal cohort study: a case study of sensitivity to imputation methods. Am J Epidemiol, 180(9), 920 - 932. DOI: 10.1093/aje/kwu224

Silins E, Horwood LJ, Patton GC, Fergusson DM, Olsson CA, Hutchinson DM, Spry E, Toumbourou JW, Degenhardt L, Swift W, Coffey C, Tait RJ, Letcher P, Copeland J, Mattick RP, Cannabis Cohorts Research Consortium . (2014). Young adult sequelae of adolescent cannabis use: an integrative analysis. Lancet Psychiatry, 1(4), 286 - 293. DOI: 10.1016/S2215-0366(14)70307-4

0

Spry E, Aarsman S, Youssef GJ, patton G, Macdonald JA, Sanson A, Thomson K, Hutchinson D, Letcher P, Olsson C. (). Maternal and paternal depression and anxiety and offspring infant negative affectivity: A systematic review and meta-analysis . DOI: 10.31234/osf.io/y9s7w

Study Contacts
Principal investigator/s	Craig Olsson
Project manager	Carolina Murphy
Study Contact	Email: 2000stories@mcri.edu.au Phone: 1800 706 101